In principle, every person has a tendency to get sick some bipolar disorder. Why is ill individually, it is still unclear. It is believed that there are a number of different reasons, which are often in varying combinations cause the occurrence of the disease buy seroquel online. A brief overview of the most important suspected causes of disease.
1. Genetic causes. Bipolar disorder is not a hereditary disease in the classical sense, but a strong genetic component is also present. The reason is not a single gene, and a set of genes, for example, for the regulation of neurotransmitters in the brain. Compared with the general population the risk of bipolar disorder in first-degree relatives (brothers, sisters), seven times higher. However, it is not excluded and that traumatic life events or authoritarian parenting style involved in the development of the disease. The results of studies of adopted children also showed an increased risk of bipolar disorders. Studies of identical twins have revealed the following pattern: If one of the twins fell ill with bipolar disorder, the probability of the disease in the second ranged from 60 to 80 percent. In other words, despite similar hereditary characteristics, 40 percent of the twins were healthy. Obviously there are many other factors that play an important role. You also need to remember that genes are also not only "dictate" determine, but also "wake up", for example, under the influence of stress factors. Thus, environmental, and genetic factors influence each other.
2. Changes in the exchange of neurotransmitters and nerve cell changes. Neurotransmitters are biologically active chemical substance of the brain that transmit data signals between nerve cells. Simply put, it undergoes changes mainly neurotransmitters norepinephrine, serotonin and dopamine. It is assumed that the concentration of these neurotransmitters is reduced during the depression, and manic periods increases. This model is based on a mechanism of action of many drugs. The nerve cell via neurotransmitters actuated variety of processes, the sequence of which in turn may be impaired. There is an assumption that each phase of the disease as it "paves the way certain" in the structure of nerve cells, which favors the occurrence of repeated episodes. Accordingly, it is important in the treatment of bipolar disorders is attached to prevent repeated phase. In general, the occurrence of episodes with a whole range of different manifestations of complex processes responsible. The interaction of these processes can be compared with the Mobile - suspended interior decoration in which every single part of the oscillation is immediately transferred to the others, and if any figure in this Mobile starts to move, the balance is disturbed other figures. Hence it becomes obvious that sometimes you want to make several attempts at therapy until there is an effective treatment.
3. Stress and major life events. Stress can take many forms. What for one person seems a positive development in life, like the upcoming birthday, another may be perceived as "stress", whether it is due to the inability to adapt to circumstances, or because of a sense of psychological overload. Shift work, separation, family or financial worries, coupled with individual vulnerability due to contribute to the development of the disease. Chronic stress in turn leads to repeated episodes of disease.
Many patients have reported that the high duration of the new episodes of the disease often causes stress, which previously, before the disease was seen as a minor, and thus it could be argued that the disease is in its course of developing certain internal dynamics.
Lack of sleep and bad days in a similar mode, promote the development of recurrent episodes, as well as alcohol and drug use.
4. Anthropological models. For in-depth understanding of the nature of bipolar disorder is not sufficient to operate only the biological and genetic explanatory models of human needs to be considered in all its diversity, and interpret the disease in this approach.
People suffering from depression often strongly absorb the prevailing norms of social behavior. During periods of mania, these norms are being questioned provocative manner, although more often than not completely rejected.
Both phases have some common features: an altered perception of time, a feeling of emptiness and meaninglessness. Both phases vzaimoobuslavlivayut waves reinforce each other: Who is experiencing mania in full, can bring yourself to such a huge depletion that depression will follow by itself. Conversely, it is possible to fall into such a deep depression that access to the "surface" is only saved in the mania. Depression and mania may be the expression of an insufficient sense of self-worth. Resentment is increasing due to prior experience. Depression brings man into a vicious circle samoobestsenivaniya. However, during the manic euphoria, a sense of self-worth is not actually strengthened, there is lingering humiliation, it is evident in the negative reactions of others and the inevitable feeling of physical exhaustion.
Both states, mania and depression means not only frustration, but at the same time stabilizing the internal emotional balance, although temporary and insufficient. Mania relieves helping overcome fear. The deep depression protects restricting sense of despair and inner confusion impede the implementation of suicidal intentions.
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